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Publication Detail
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Traditional and accelerator mass spectrometry for quantitation of human folate pools
Publish date: 2005
Author: Stephen R. Dueker, Michael Lamé, Yumei Lin, Andrew J. Clifford, Bruce A. Buchholz and John S. Vogel
Source: Trends in Food Science & Technology 16 (2005) 267-270
Folate is a structurally diverse family of molecules that occur
in low concentrations in biological tissues and fluids and
therefore present complex challenges to the analytical
chemist. As a result, techniques that quantify folates in
biological specimens have emerged as a high scientific
priority. In this manuscript, isotopic methods using traditional
mass spectrometry for the measurement of whole
blood total folate and 14C-accelerator mass spectrometry
(AMS) for human kinetic studies are presented. Additionally,
recent developments with the intrinsic labeling of spinach
folate from a [14C]-para-aminobenzoic is discussed.
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